familial hypercholesterolemia
noun
: an inherited metabolic disorder marked by excess accumulation of LDL cholesterol in the blood resulting especially in atherosclerosis and irregular yellow skin lesions
Examples of familial hypercholesterolemia in a Sentence
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Some people need to limit cholesterol-rich foods, like egg yolks, such as those with familial hypercholesterolemia.
—
Jillian Kubala, Health, 8 Oct. 2025
Other heart conditions, like familial hypercholesterolemia (high cholesterol) and high lipoprotein (a) (proteins and fats that carry cholesterol), can be inherited, and a family history of heart disease that isn’t genetic puts you at higher risk, too.
—Sarah Klein, TIME, 11 Apr. 2024
The 10 patients in this Phase 1 trial had heterozygous familial hypercholesterolemia, a genetic disease that causes high levels of bad cholesterol and advanced heart disease.
—Meghana Keshavan, STAT, 13 Nov. 2023
Verve's research was limited to people with a genetic condition called heterozygous familial hypercholesterolemia, in which cholesterol levels are sky-high from birth.
—Erika Edwards, NBC News, 12 Nov. 2023
Each had a genetic abnormality, familial hypercholesterolemia, that affects around one million people in the United States.
—Gina Kolata, New York Times, 12 Nov. 2023
Although the trial is focused on people with the genetic condition familial hypercholesterolemia, Kathiresan hopes the one-and-done therapy may one day be used more broadly, to permanently reduce the risk of heart disease in millions of people with high cholesterol.
—Ryan Cross, BostonGlobe.com, 12 July 2022
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Jillian Kubala, Health, 8 Oct. 2025
Other heart conditions, like familial hypercholesterolemia (high cholesterol) and high lipoprotein (a) (proteins and fats that carry cholesterol), can be inherited, and a family history of heart disease that isn’t genetic puts you at higher risk, too.
—Sarah Klein, TIME, 11 Apr. 2024
The 10 patients in this Phase 1 trial had heterozygous familial hypercholesterolemia, a genetic disease that causes high levels of bad cholesterol and advanced heart disease.
—Meghana Keshavan, STAT, 13 Nov. 2023
Verve's research was limited to people with a genetic condition called heterozygous familial hypercholesterolemia, in which cholesterol levels are sky-high from birth.
—Erika Edwards, NBC News, 12 Nov. 2023
Each had a genetic abnormality, familial hypercholesterolemia, that affects around one million people in the United States.
—Gina Kolata, New York Times, 12 Nov. 2023
Although the trial is focused on people with the genetic condition familial hypercholesterolemia, Kathiresan hopes the one-and-done therapy may one day be used more broadly, to permanently reduce the risk of heart disease in millions of people with high cholesterol.
—Ryan Cross, BostonGlobe.com, 12 July 2022
Cite this Entry
“Familial hypercholesterolemia.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/familial%20hypercholesterolemia. Accessed 31 Oct. 2025.
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